Decibel Therapeutics (Nasdaq: DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, announced today that it will present two digital presentations at the American Society of Gene and Cell Therapy (ASGCT) 24^th Annual Meeting, to be held virtually May 11-14, 2021. The digital presentations will highlight Decibel’s innovative platform and provide data on DB-OTO, Decibel’s gene therapy being developed in collaboration with Regeneron Pharmaceuticals to restore hearing in children with a deficiency in the otoferlin gene.

Presentation details are as follows:

Abstract number: 579
Title: Development of an AAV-Based Gene Therapy for Children with Congenital Hearing Loss Due to Otoferlin Deficiency (DB-OTO)
Summary: An overview of preclinical DB-OTO data from mice and non-human primates
Date and time: Tuesday May 11, 2021, 8:00 a.m. – 10:00 a.m. ET

Abstract number: 536
Title: Mechanisms of Promoter-Driven AAV Toxicity in the Ear
Summary: An overview of potential mechanisms of ubiquitous promoter-driven AAV toxicity in the ear
Date and time: Tuesday May 11, 2021, 8:00 a.m. – 10:00 a.m. ET

About Decibel Therapeutics

Decibel Therapeutics is a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, one of the largest areas of unmet need in medicine. Decibel has built a proprietary platform that integrates single-cell genomics and bioinformatic analyses, precision gene therapy technologies and expertise in inner ear biology. Decibel is leveraging its platform to advance gene therapies designed to selectively replace genes for the treatment of congenital, monogenic hearing loss and to regenerate inner ear hair cells for the treatment of acquired hearing and balance disorders. Decibel’s pipeline, including its lead gene therapy program, DB-OTO, to treat congenital, monogenic hearing loss, is designed to deliver on our vision of a world in which the privileges of hearing and balance are available to all.

Investor Contact:
Julie Seidel
Stern Investor Relations, Inc.
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212-362-1200

Media Contact:
Chris Railey
Ten Bridge Communications
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617-834-0936