TEL AVIV, Israel, Aug. 21, 2024 (GLOBE NEWSWIRE) -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB), (Chemomab), a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need, today announced financial and operating results for the second quarter ended June 30, 2024, and provided a corporate update.
“This past period has been an exciting time of transformation for Chemomab. The positive results of the Phase 2 SPRING trial represent a major milestone for the company and clearly establish clinical proof-of-concept for CM-101 in primary sclerosing cholangitis (PSC) and potentially other fibrotic diseases,” said Adi Mor, PhD, co-founder, Chief Executive Officer and Chief Scientific Officer of Chemomab. “CM-101 achieved the primary and key secondary endpoints in the trial and is the first therapy to demonstrate broad, clinically relevant effects on the three main components of PSC. This is also the first PSC trial to show, after just 15 weeks of treatment, a statistically significant reduction in liver stiffness, a widely used and well validated measure for assessing disease progression in PSC.”
“We believe these results provide strong support for advancing CM-101 to a Phase 3 PSC trial, which we are in the process of planning and will be discussing with the FDA during the End-of-Phase 2 meeting targeted for later this year. We anticipate two milestones early in 2025 – additional data from the open label extension portion of the SPRING trial and finalization of the PSC Phase 3 design reflecting our discussions with the FDA. Based on recent developments in related indications, we are optimistic that an accelerated approval design incorporating surrogate biomarkers may be feasible for CM-101.”
Dr. Mor continued, “We were pleased to welcome existing and major new investors, including OrbiMed, HBM Partners and Sphera, who participated in our successful $10 million PIPE financing. The proceeds generated by this financing will enable us to achieve our upcoming milestones in early 2025 and fund the operations of the company through the beginning of 2026.”
Dr. Mor concluded, “As a first-in-class molecule with a promising novel target relevant to multiple fibro-inflammatory diseases, CM-101 has long been of interest to potential biopharma partners. As expected, the positive data reported from the Phase 2 SPRING trial provides us opportunities to further advance the optimal path forward for CM-101, including potentially partnering to accelerate timelines for CM-101 development in PSC and other indications.”
Second Quarter 2024 and Recent Updates
Second Quarter 2024 Financial Highlights
Forward Looking Statements
This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties, in particular, the statements regarding our resulting cash runway. All statements other than statements of historical facts contained in this presentation, including statements regarding our future financial condition, results of operations, business strategy and plans, and objectives of management for future operations, as well as statements regarding industry trends, are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “estimate,” “intend,” “may,” “plan,” “potentially” “will” or the negative of these terms or other similar expressions. We have based these forward-looking statements largely on our current expectations and projections about future events and trends that we believe may affect our financial condition, results of operations, business strategy and financial needs. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including, among other things: the company’s ability to ensure its cash runway extends through early 2026; the likelihood that the company can partner with other biopharma companies to accelerate timelines for CM-101 development in PSC and other indications; the risk that the full data set from the CM-101 study or data generated in further clinical trials of CM-101 will not be consistent with the topline results of the CM-101 Phase 2 PSC trial; failure to obtain, or delays in obtaining, regulatory approvals for CM-101 in the U.S., Europe or other territories; failure to successfully commercialize CM-101, if approved by applicable regulatory authorities, in the U.S., Europe or other territories, or to maintain U.S., European or other territory regulatory approval for CM-101 if approved; uncertainties in the degree of market acceptance of CM-101 by physicians, patients, third-party payors and others in the healthcare community; inaccuracies in the Company's estimates of the size of the potential markets for CM-101 or in data the Company has used to identify physicians; expected rates of patient uptake, duration of expected treatment, or expected patient adherence or discontinuation rates; development of unexpected safety or efficacy concerns related to CM-101; failure to successfully conduct future clinical trials for CM-101, including due to the Company's potential inability to enroll or retain sufficient patients to conduct and complete the trials or generate data necessary for regulatory approval, among other things; risks that the Company's clinical studies will be delayed or that serious side effects will be identified during drug development; failure of third parties on which the Company is dependent to manufacture sufficient quantities of CM-101 for commercial or clinical needs, to conduct the Company's clinical trials, or to comply with the Company's agreements or laws and regulations that impact the Company's business or agreements with the Company; the strength and enforceability of the Company’s intellectual property rights or the rights of third parties; the cost and potential reputational damage resulting from litigation to which the Company may become a party, including product liability claims; changes in laws and regulations applicable to the Company's business and failure to comply with such laws and regulations; business or economic disruptions due to catastrophes or other events, including natural disasters or public health crises; and inability to repay the Company's existing indebtedness and uncertainties with respect to the Company's need and ability to access future capital; and the intensity and duration of the current war in Israel, and its impact on our operations in Israel. These risks are not exhaustive. You should carefully consider the risks and uncertainties described in the “Risk Factors” sections of our 20-F for the year ended December 31, 2023. New risk factors emerge from time to time, and it is not possible for our management to predict all risk factors, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in, or implied by, any forward-looking statements. You should not rely upon forward-looking statements as predictions of future events. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements. Except as required by law, we undertake no obligation to update publicly any forward-looking statements for any reason after the date of this press release.
About Chemomab Therapeutics Ltd.
Chemomab is a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need. Based on the unique and pivotal role of the soluble protein CCL24 in promoting fibrosis and inflammation, Chemomab developed CM-101, a monoclonal antibody that neutralizes CCL24 activity. In clinical and preclinical studies, CM-101 has been shown to have a favorable safety profile and has been generally well-tolerated to date, with the potential to treat multiple severe and life-threatening fibro-inflammatory diseases. Chemomab has reported positive results from four clinical trials of CM-101 in patients, including a Phase 2 trial in patients with primary sclerosing cholangitis (PSC), a Phase 2a liver fibrosis trial in patients with metabolic dysfunction-associated steatohepatitis (MASH), a Phase 1b study in patients with metabolic dysfunction–associated fatty liver disease (MAFLD) and an investigator-initiated study in patients with severe lung injury. Chemomab’s CM-101 program for the treatment of systemic sclerosis is Phase 2-ready with an open U.S. IND. For more information, visit www.chemomab.com.
Contacts:
Media & Investors:
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Barbara Lindheim
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Investor & Public Relations,
Strategic Communications
Phone: +1 917-355-9234
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Interim Condensed Consolidated Balance Sheets (Unaudited) | |||||||
In USD thousands (except for share amounts) | |||||||
June 30, | December 31, | ||||||
2024 | 2023 | ||||||
Assets | |||||||
Current assets | |||||||
Cash and cash equivalents | 5,036 | 9,292 | |||||
Short term bank deposits | 7,691 | 10,492 | |||||
Restricted cash | 74 | 76 | |||||
Other receivables and prepaid expenses | 654 | 1,037 | |||||
Total current assets | 13,455 | 20,897 | |||||
Non-current assets | |||||||
Long term prepaid expenses | 472 | 559 | |||||
Property and equipment, net | 276 | 303 | |||||
Operating lease right-of-use assets | 341 | 392 | |||||
Total non-current assets | | 1,089 | 1,254 | ||||
Total assets | 14,544 | 22,151 | |||||
Current liabilities | |||||||
Trade payables | 1,113 | 516 | |||||
Accrued expenses | 2,546 | 3,423 | |||||
Employee and related expenses | 540 | 823 | |||||
Operating lease liabilities | 109 | 76 | |||||
Total current liabilities | 4,308 | 4,838 | |||||
Non-current liabilities | |||||||
Operating lease liabilities - long term | 251 | 316 | |||||
Total non-current liabilities | 251 | 316 | |||||
Commitments and contingent liabilities | |||||||
Total liabilities | 4,559 | 5,154 | |||||
Shareholders' equity (*) | |||||||
Ordinary shares no par value - Authorized: 4,650,000,000 shares as of June 30, 2024 and 650,000,000 shares as of December 31, 2023; | - | - | |||||
Issued and outstanding: 287,183,800 Ordinary shares as of June 30, 2024 and 284,094,700 as of December 31, 2023; | - | - | |||||
Additional paid in capital | 106,162 | 105,675 | |||||
Accumulated deficit | (96,177 | ) | (88,678 | ) | |||
Total shareholders’ equity | 9,985 | 16,997 | |||||
Total liabilities and shareholders’ equity | 14,544 | 22,151 |
(*) 1 American Depositary Share (ADS) represents 20 Ordinary Shares
Interim Condensed Consolidated Statements of Operations (Unaudited) | ||||||||
In USD thousands (except for share and per share amounts) | ||||||||
Three months | Three months | Six months | Six months | |||||
Ended | Ended | Ended | Ended | |||||
June 30, | June 30, | June 30, | June 30, | |||||
2024 | 2023 | 2024 | 2023 | |||||
Operating expenses | ||||||||
Research and development | 2,928 | 5,020 | 6,080 | 11,907 | ||||
General and administrative | 840 | 3,175 | 1,736 | 5,337 | ||||
Total operating expenses | 3,768 | 8,195 | 7,816 | 17,244 | ||||
Financing income, net | 137 | 259 | 317 | 576 | ||||
Loss before taxes | 3,631 | 7,936 | 7,499 | 16,668 | ||||
Taxes on income | - | 34 | - | 55 | ||||
Net loss for the period | 3,631 | 7,970 | 7,499 | 16,723 |
Basic and diluted loss per Ordinary Share (*) | 0.013 | 0.036 | 0.026 | 0.076 |
Weighted average number of Ordinary Shares outstanding, basic, and diluted (*) | 286,080,133 | 221,674,130 | 285,111,876 | 221,338,951 |
(*) 1 American Depositary Share (ADS) represents 20 Ordinary Shares
Last Trade: | US$1.57 |
Daily Change: | -0.07 -4.27 |
Daily Volume: | 83,183 |
Market Cap: | US$22.550M |
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