Amyris, Inc. (Nasdaq: AMRS), a leading synthetic biotechnology company accelerating the world to sustainable consumption through its Lab-to-Market^TM operating platform, today announced financial results for its third quarter ended September 30, 2021.

"Amyris delivered another strong quarter along with solid strategic execution amid challenging external global supply chain conditions," said John Melo, President and Chief Executive Officer. "Once again, we realized record underlying revenue and record consumer revenue demonstrating continued year-over-year and sequential growth. We launched four new consumer brands in the quarter further expanding our foothold in clean beauty and personal care end-markets. Rose Inc.^TM clean color cosmetics, JVN^TM clean haircare and Terasana® clean skincare are each formulated with one, or a combination, of our unique sustainable ingredients that we created and manufacture leveraging the power of our Lab-to-Market^TM operating platform. Additionally, we launched Olika^TM. We completed three acquisitions including Olika, Beauty Labs and MG Empower adding strategic digital, online influencer and social selling capabilities as approximately 50% of our consumer revenue is being generated from e-commerce which is our fastest growing and best gross margin business channel."

"Our science and partnerships continue to deliver new opportunities. We are very excited about our JV partnership with ImmunityBio for the commercialization of a second generation COVID-19 vaccine which expands our business into biopharma. We continued to progress the construction of our new Brazil ingredients plant with expected production in early 2022 as well as the establishing our consumer production facility in Reno, Nevada by the middle of next year."

"Worldwide supply chain disruptions combined with late quarter launches of the new brands resulted in lower-than-expected revenue. Shipping delays impacted supply of raw materials and customer shipments while freight expense significantly increased. Although global in nature and persisting in the fourth quarter, we believe these are short-term issues and that they have no impact on our long-term growth targets. We continue to experience very robust demand that more than supports our outlook. Looking ahead to 2022, we are taking control of our supply chain with the investments in Brazil and Reno to reduce our third-party dependency and our exposure to shipping delays resulting in lower operating costs and expanded gross margins. We now expect full year 2021 total revenue to be in the $330 - $370 million range, doubling full year 2020. We have the inventory on hand to deliver within this range and subject to easing supply chain headwinds could attain upside."

"We continue to strategically progress our capital structure to eliminate remaining legacy debt and bring in growth capital to support our ambitious operational and financial growth targets."

Business and Operational Highlights

• Record Q3 underlying revenue of $48 million increased 40% continuing the year-over-year and sequential growth trajectory. Record consumer revenue of $23 million increased 89% versus Q3 2020. The total number of consumer brands grew from 1 in 2018, and 3 in 2019, to 8 in Q3 2021. Year-to-date Q3 2021 consumer revenue of $60 million grew from $6 million for the same period in 2018, 10.7X or a 121% CAGR.
• During September, Rose Inc. and JVN hosted a number of launch events in the U.S. and internationally, including social media campaigns to accelerate brand awareness and educate consumers on the power of Squalane, Hemi-Squalane and Biosilica as differentiated core ingredients to these brands. JVN was launched with 9 SKUs in 62 Sephora stores with stores expected to triple over the next quarter. Rose Inc. was launched with 16 SKUs in Sephora North America and Space NK in the U.K. Both brands are accelerating revenue into the fourth quarter and are expected to exceed $20 million revenue each in their first 12 months. This would be our strongest performance for new brands
• Biossance®'s international expansion continued through Space NK in the U.K. and can now be found in 14 different retailer chains worldwide. Pipette continued to deliver on its commitment to improve the accessibility of clean products for babies, mothers and families. Pipette can now be found in 236 new stores across Canada and also launched in 118 new stores in the U.S. during Q3.
• Amyris and ImmunityBio (Nasdaq: IBRX) announced a JV for the commercialization of a next-generation COVID-19 RNA vaccine. Upon completion of successful human trials, the joint-venture's goal is to deliver one billion doses of the new vaccine in 2022 addressing the unmet needs of access to vaccines in developing countries and other regions of the world, addressing cold-chain and durability challenges facing the world today.
• Through the end of Q3 sales volumes for Squalane, used in skin care and other products, surpassed total 2020 sales volumes. Demand for Hemi-Squalane for haircare, is driven by increasing regulatory pressure to reduce the use of environmentally harmful silicones.
• Q3 was critical for our consumer supply chain to support brand launches and to also prepare for the end-of-year holiday season. 90% of projected product demand is in our distribution centers available for sale. During Q3 we experienced supply chain challenges with significant port delays for critical raw materials due to labor shortages affecting the production of Squalane and Hemi-Squalane. These delays resulted in a 20% shortfall in our Squalane production target. We incurred additional cost from increased shipping expense and expedited air shipping. We anticipate shipping and port unloading issues to continue in Q4.
• We continued to manage COVID-19 with a very successful management and monitoring program while having 250-300 construction workers at the Brazil ingredients plant construction site. Commodity cost increases affected the cost of construction materials such as steel. Commissioning of the plant remains on schedule for early 2022.
• We expect to finalize negotiations for three new consumer brands over the next three months. These are strategic additions and represent significant opportunity for our ingredient portfolio.

Q3 and YTD 2021 Sales Revenue

¹ Other: $4.8m Vitamin E transaction (Q1 2020), $143.6m DSM F&F transaction (Q1 2021), $10.0m Ingredion Reb M transaction (Q2 2021).

Q3 2021 Financial Highlights

• Total revenue of $47.9 million, increased 40% compared to Q3 2020 revenue of $34.3 million. Product revenue of $36.5 million increased 17% compared to Q3 2020 product revenue of $31.1 million driven by record consumer revenue of $23.2 million, an 89% increase, which was partially offset by a decrease in ingredient sales.
• Non-GAAP gross margin of $17.7 million, or 37% of revenue, grew from $14.2 million, or 41% of revenue in Q3 2020 primarily due to increased consumer revenue.
• Cash operating expense of $81.4 million increased by $38.1 million, or 88%, compared to Q3 2020, primarily due to a $28.1 million increase in selling expense due to higher headcount, growth driven fulfillment and shipping expense and launches of new brands. R&D and G&A expense increased by $4.4 million and $5.6 million respectively due to higher headcount, M&A expense and comparatively low prior year travel expense due to COVID-19.
• Adjusted EBITDA of -$73.1 million decreased $40 million year-over-year, primarily due to higher operating expense.
• GAAP net income/loss is significantly influenced by non-cash mark-to-market adjustments related to changes in the fair value of debt and derivatives. GAAP net loss of $32.9 million or $0.11 per share compared to a loss of $83.5 million or $0.37 per share in Q3 2020. Adjusted net loss of $80.1 million, or $0.27 per share, compared to an adjusted net loss of $50.0 million, or $0.22 per share in Q3 2020.
• Cash at the end of the quarter was $115 million, compared to $38 million at the end of Q3 2020.
• Total debt principal at the end of the quarter was $102 million, compared to $175 million at the end of Q3 2020. Interest expense for Q3 2021 was $4 million compared to $7 million in Q3 2020 due to reduced debt.

YTD 2021 Financial Highlights

• Total YTD revenue of $277.0 million improved 197% versus the prior year period. Total revenue included $153.6 million of proceeds resulting from strategic transactions. Total underlying revenue (product and R&D and other services) increased 39% to $123.4 million compared to $88.6 million in first 9 months of 2020. Product revenue of $102.1 million increased $25.5 million, or 33%, compared to the first 9 months of 2020 driven by a $25.2 million, or 73%, increase in consumer sales.
• Non-GAAP gross margin of $205.0 million, or 74% of revenue, grew from $43.5 million or 47% of revenue in first nine months of 2020. Excluding the contribution from the strategic transactions, gross margin of $51.4 million grew $12.8 million compared to first nine months of 2020 primarily due to consumer-related growth.
• Cash operating expense of $198.0 million increased by $67.5 million, or 52%, compared to first 9 months of 2020 primarily due to investments in consumer brands, new consumer brand launches, increased headcount and additional R&D spend.
• Adjusted EBITDA of -$12.2 million improved $84.4 million year-over-year due to revenue and margin growth and proceeds from strategic transactions.
• GAAP net loss was $308.0 million or $1.07 per share compared to a loss of $273.2 million or $1.44 per share in the first 9 months of 2020. Adjusted net loss was $34.2 million, or $0.12 per share compared to adjusted net loss of $152.2 million, or $0.80 per share, for the first 9 months of 2020.

Outlook – Update to Guidance Provided on August 5, 2021

• Amyris now expects reported total revenue for the full year, inclusive of strategic transactions of $154 million, to be in a range of $330 - $370 million.

Conference Call

Amyris will host its third quarter 2021 conference call today at 4:30 pm ET (1:30 pm PT) to discuss its financial results and provide a business and financial update.

Live audio webcast/conference call:

Webcast: please visit http://investors.amyris.com.

U.S. Dial-In Number: (844) 850-0551. International Dial-In Number: (412) 902-4203.

Please connect to the website or dial in to the conference call 15 minutes prior to the start of the call to avoid connection delays. If a participant will be listen-only, they are encouraged to listen via the webcast on Amyris' investor page.

A replay of the webcast will be available on the Investor Relations section of Amyris' website.

FINANCIAL RESULTS AND NON-GAAP INFORMATION

To supplement our financial results and guidance presented in accordance with U.S. generally accepted accounting principles (GAAP), we use certain non-GAAP financial measures that we believe are helpful in understanding our financial results. These non-GAAP financial measures are among the factors management uses in planning and forecasting future periods. These non-GAAP financial measures also facilitate management's internal comparisons to Amyris' historical performance as well as comparisons to the operating results of other companies. Management believes these non-GAAP financial measures, when considered together with financial information prepared in accordance with GAAP, can enhance investors' and analysts' abilities to meaningfully compare our results from period to period, identify operating trends in our business, and track and model our financial performance. In addition, our management believes that these non-GAAP financial measures allow for greater transparency into the indicators used by management to understand and evaluate our business and make operating decisions.

Non-GAAP financial information is not prepared under a comprehensive set of accounting rules, and therefore, should only be read in conjunction with financial information reported under GAAP in order to understand Amyris' operating performance. A reconciliation of the non-GAAP financial measures presented in this release to the most directly comparable GAAP financial measure, is provided in the tables attached to this press release.

Our Non-GAAP financial measures include the following:

Non-GAAP Gross Margin (Gross Margin) is calculated as GAAP revenue less non-GAAP cost of products sold divided by GAAP revenue. Non-GAAP cost of products sold excludes other costs/provisions, inventory lower of cost or net realizable value adjustments, excess capacity, manufacturing capacity fee adjustments, stock-based compensation expense, depreciation and amortization.

Non-GAAP Cash Operating Expense is calculated as GAAP Operating Expense minus non-cash stock-based compensation, depreciation and amortization, non-recurring transaction and acquisition expense, contract credit loss reserve, and R&D performance agreement termination.

EBITDA is calculated as GAAP net income (loss) less interest, expense, income tax expense, depreciation and amortization expense, deemed dividends to preferred stockholders, and loss allocated to participating securities.

Adjusted EBITDA is calculated as EBITDA less income attributable to noncontrolling interest, gain/loss from change in fair value of derivatives, gain/loss from changes in the fair value of debt, loss upon debt extinguishment, other income/expense, loss from investment in affiliate, inventory lower of cost or net realizable value adjustments, non-recurring transaction and acquisition expense, stock-based compensation expense, R&D performance agreement termination, manufacturing capacity fee adjustment and contract asset credit loss reserve.

Adjusted net income (loss) is calculated as GAAP net income/loss excluding stock-based compensation expense, gain/loss from change in fair value of derivatives, gain/ loss from changes in the fair value of debt, losses upon debt extinguishment, income/loss attributable to noncontrolling interest, loss allocated to participating securities, inventory lower of cost or net realizable value adjustments, R&D performance agreement termination, manufacturing capacity fee adjustments, non-recurring transaction and acquisition expense, other income/expense, and gain/loss from investment in affiliate.

Adjusted EPS is calculated by dividing adjusted net income (loss) by the weighted average shares, basic outstanding for the period.

About Amyris

Amyris (Nasdaq: AMRS) is a leading synthetic biotechnology company, transitioning the Clean Health & Beauty and Flavors & Fragrances markets to sustainable ingredients through fermentation and the company's proprietary Lab-to-Market^TM operating platform. This Amyris platform leverages state-of-the-art machine learning, robotics and artificial intelligence, enabling the company to rapidly bring new innovation to market at commercial scale. Amyris ingredients are included in over 20,000 products from the world's top brands, reaching more than 300 million consumers. Amyris also owns and operates a family of consumer brands that is constantly evolving to meet the growing demand for sustainable, effective and accessible products. For more information, please visit http://www.amyris.com.

Amyris, the Amyris logo, No Compromise, Biossance, Pipette, Purecane, Terasana, Rose Inc. and Lab-to-Market are trademarks or registered trademarks of Amyris, Inc. in the U.S. and/or other countries.

Forward-Looking Statements

This release contains forward-looking statements, and any statements other than statements of historical fact could be deemed to be forward-looking statements. These forward-looking statements include, among other things, statements regarding future events, such as Amyris' financial outlook and goals for the remainder of 2021 and beyond; Amyris' expectations regarding supply chain issues in Q4 and beyond and the limited impact of such issues on long-term growth targets; Amyris' expectations about increasing consumer demand for sustainable products and the acceleration of revenue of newly launched brands; Amyris' expectations regarding its JV partnership with ImmunityBio and the development, manufacturing, and commercialization of its COVID-19 vaccine which expands its business into biopharma and the timing thereof; Amyris' expectation of adding three new consumer brands and the timing thereof; and Amyris' expectations regarding the commissioning of its Brazil manufacturing facility, the timing thereof and benefits thereof in alleviating cost pressures. These statements are based on management's current expectations and actual results and future events may differ materially due to risks and uncertainties, including risks related to Amyris' liquidity and ability to fund operating and capital expenses, risks related to its financing activities, risks related to potential delays or failures in completing and integrating planned acquisitions, risks related to potential delays or failures in development, regulatory approval, launch, production and commercialization of products, risks related to Amyris' reliance on third parties particularly in the supply chain, and other risks detailed from time to time in filings Amyris makes with the Securities and Exchange Commission, including Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. Amyris disclaims any obligation to update information contained in these forward-looking statements, whether as a result of new information, future events, or otherwise.

Financial Tables Follow