Amyris, Inc. (Nasdaq: AMRS), a leading synthetic biotechnology company active in the Clean Health and Beauty markets through its consumer brands, today announced financial results for its fourth quarter and full year ended December 31, 2020.

"2020 was a year of transformative execution for Amyris," said John Melo, President and Chief Executive Officer of Amyris. "We delivered the third consecutive quarter of record Product sales revenue in Q4 while also expanding Product gross margins. We continued to see strong growth with our Consumer brands and delivered Q4 Consumer revenue equivalent to the entire year 2019. This revenue and margin growth combined with the completion of the strategic transaction resulted in positive adjusted EBITDA in the quarter."

Mr. Melo added, "The Amyris team made significant progress in 2020 on our strategic initiatives. We delivered six new ingredients at scale, completed a successful $200 million equity financing and significantly reduced our total debt. With the momentum in our product revenue we believe that we are well positioned to continue to drive sector leading growth into the future. We expect 2021 to be another record year with underlying total revenue in the $240 million range and reported total revenue of around $400 million, when including the potential impact of the strategic transactions. With our business momentum and these transactions, we expect to deliver full year 2021 positive adjusted EBITDA."

Q4 2020 Financial Highlights

• Record sales revenue of $80 million nearly doubled versus the prior year quarter. Record Product revenue of $35 million increased 71% compared to the prior year quarter driven by a record quarter for Consumer which, with $17 million in revenue and 161% growth, delivered as much revenue in Q4 as the entire year 2019. Ingredients revenue of $18 million grew 29%. Q4 revenue included $40 million for the Farnesene strategic transaction.
• Gross margin of 66% improved from 56% in the prior year quarter and increased $30 million year-over-year. Product-related gross margin grew $6 million versus the prior year quarter with the remaining $24 million primarily attributable to the year-over-year impact from strategic transactions.
• Cash operating expense of $50 million increased by $5 million or 10% versus the prior year quarter, primarily due to marketing investments in our consumer brands and new R&D programs.
• Adjusted EBITDA was positive $1 million and improved $26 million year-over-year due to higher revenue, improved Product gross margins, and income from the Q4 strategic transaction.
• GAAP net earnings were -$109 million due mostly to -$98 million of unfavorable mark-to-market non-cash adjustments related to changes in the fair value of debt and derivatives. GAAP EPS of -$0.44 basic improved from -$0.65 basic in the prior year quarter.
• Adjusted net earnings of -$7 million improved $34 million compared to the prior year quarter. Adjusted EPS of -$0.03 compared with -$0.34 for Q4 2019.
• Debt of $171 million was significantly reduced by $127 million from $297 million in the prior year quarter resulting in reduced interest expense of $6 million or 56% compared to the prior year quarter.

Full Year 2020 Financial Highlights

• Record sales revenue of $173 million grew 13% versus the prior year. Record Product revenue of $112 million increased 72% versus the prior year driven by record Consumer revenue and record Ingredients growth, up 197% and 26% respectively.
• Gross margin of 56% improved $11 million compared to the prior year. Product-related gross margin grew $37 million year-over-year, with a $23 million improvement from Consumer and a $14 million increase from Ingredients. 2019 saw higher income from Collaboration and transactions resulting in a year-over-year variance of -$26 million.
• Cash operating expense of $181 million decreased by $1 million or 1% compared to the prior year primarily due to decreases in G&A and R&D expenses partly offset by increases in marketing expenses to support consumer brands growth.
• Adjusted EBITDA of -$95 million improved $8 million compared to the prior year, primarily due to higher revenue and improved gross margins.
• GAAP net earnings were -$382 million due mostly to -$232 million of mark-to-market non-cash adjustments related to changes in the fair value of debt and derivatives, extinguishment of debt and deemed dividends. GAAP EPS of -$1.88 basic improved from -$2.67 basic in the prior year.
• Adjusted net earnings of -$151 million improved $16 million compared to 2019. Adjusted EPS of -$0.74 compared with -$1.65 for the prior year.

Q4 2020 and Full Year Sales Revenue

Full Year 2021 Outlook

• Underlying total revenue (Product, Collaboration & Grants) expected to be in the $240 million range. Reported total revenue expected to be around $400 million.
• Phasing of Underlying total revenue expected to be 35% H1 and 65% H2 to reflect a continued quarter-on-quarter growth trajectory and the addition of new brands.
• Debt per end of 2020 of $171 million expected to reduce further to below $100 million by Q3 2021.
• Strategic transactions expected to be mostly accretive to revenue and earnings resulting in positive full year adjusted EBITDA. The company may update its full year 2021 outlook following completion of the strategic transactions.

Strategic Highlights

1.    High growth consumer brands: industry-leading growth

• Recent progress:
  • Biossance^® / SuperOrdinary partnership for China launch. First order shipped in Q4.
• Upcoming milestones:
  • Q1 2021 acquisition of Costa Brazil luxury clean beauty brand.
  • Q3 2021 launch of Rose Inc. clean beauty color cosmetics brand.
  • Q3 2021 launch of JVN clean haircare brand.
  • Q2 2021 launch of Terasana brand for acne and other clean skincare treatments.

2.    Scientific and commercial collaboration: fast time from lab to industrial scale

• Recent progress:
  • Launched six new ingredients, exceeding 2020 goal of two to three.
  • Sold out first commercial production of Cannabigerol (CBG) from fermentation, understood to be largest fermentation-based CBG production in the sector to-date.
  • Expanded collaboration with DSM on Human Milk Oligosaccharides (HMO).
• Upcoming milestone:
  • Amryis/IDRI RNA COVID-19 vaccine platform advancing to phase 1 clinical trial.
  • Closing collaboration with one of the world's leading meat producers for zero carbon protein production.

3.    Supply chain optimization: enhanced product margins

• Recent progress:
  • Received Bonsucro certification for sustainable sugarcane production.
  • Ranked among world's top social and environmental impact companies by Real Leaders^®.
• Upcoming milestones:
  • Construction of Brazil plant targeted for Q4 2021 completion.
  • Publication of first ESG report.

4.    Improved balance sheet, earnings and cash flow: financial foundation for success

• Recent progress:
  • Strong Consumer and Ingredients revenue growth and improved margin profile.
  • Generated $47 million from warrants conversion from December 2020 to March 2021.
  • Debt as of March 1, 2021 reduced to below $150 million.
  • Closed first strategic transaction in Q4 valued at $50 million; $30 million received in Q4, $10 million to be received in Q1 2021, the remainder in milestone payments.
• Upcoming milestone:
  • Two additional strategic transactions expected to close and deliver an anticipated total value of $500 million for all three transactions combined.

FINANCIAL RESULTS AND NON-GAAP INFORMATION

To supplement our financial results and guidance presented in accordance with U.S. generally accepted accounting principles (GAAP), we use certain non-GAAP financial measures that we believe are helpful in understanding our financial results. These non-GAAP financial measures are among the factors management uses in planning and forecasting future periods. These non-GAAP financial measures also facilitate management's internal comparisons to Amyris's historical performance as well as comparisons to the operating results of other companies. Management believes these non-GAAP financial measures, when considered together with financial information prepared in accordance with GAAP, can enhance investors' and analysts' abilities to meaningfully compare our results from period to period, identify operating trends in our business, and track and model our financial performance. In addition, our management believes that these non-GAAP financial measures allow for greater transparency into the indicators used by management to understand and evaluate our business and make operating decisions.

Non-GAAP financial information is not prepared under a comprehensive set of accounting rules, and therefore, should only be read in conjunction with financial information reported under GAAP in order to understand Amyris's operating performance. A reconciliation of the non-GAAP financial measures presented in this release to the most directly comparable GAAP financial measure, is provided in the tables attached to this press release.

Our Non-GAAP financial measures include the following:

Adjusted net income (loss) is calculated as GAAP net income/loss excluding stock-based compensation expense, gain/loss from change in fair value of derivatives, gain/ loss from changes in the fair value of debt, losses upon debt extinguishment, income attributable to noncontrolling interest, deemed dividends to preferred stockholders, contract asset credit loss reserve, loss allocated to participating securities, contract asset credit loss reserve, inventory lower of cost or net realizable value adjustments, and other income/expense and income/loss attributable to noncontrolling interest.

Adjusted EPS is calculated by dividing Non-GAAP net income (loss) by the weighted average shares, basic outstanding for the period.

Non-GAAP Gross Margin (Gross Margin) is calculated as GAAP revenues divided by non-GAAP cost of products sold (which excludes other costs/provisions, inventory lower of cost or net realizable value adjustments, excess capacity, stock-based compensation expense, depreciation and amortization).

Non-GAAP Cash Operating Expense is calculated as GAAP Operating Expense minus non-cash stock-based compensation, depreciation and amortization and contract asset credit loss reserve.

EBITDA is calculated as GAAP net loss less interest, expense, income tax expense, depreciation and amortization, deemed dividends to preferred stockholders, and loss allocated to participating securities.

Adjusted EBITDA is calculated as EBITDA less income attributable to noncontrolling interest, gain/loss from change in fair value of derivatives, gain/loss from changes in the fair value of debt, loss upon debt extinguishment, other income/expense, loss from investment in affiliate, income attributable to non-controlling interest, inventory lower of cost or net realizable value adjustments, stock-based compensation expense, and contract asset credit loss reserve.

Conference Call

Amyris will host its fourth quarter and full year 2020 conference call today at 9:00 am ET (6:00 am PT) to discuss its financial results and provide a business and financial update.

Live audio webcast/conference call:

Webcast: please visit http://investors.amyris.com.
U.S. Dial-In Number: (877) 870-4263. International Dial-In Number: (412) 317-0790. Ask to join the Amyris, Inc. call.

Please connect to the website or dial in to the conference call 15 minutes prior to the start of the call to avoid connection delays. If a participant will be listen-only, they are encouraged to listen via the webcast on Amyris's investor page.

A replay of the webcast will be available on the Investor Relations section of the company's website.

About Amyris
Amyris (Nasdaq: AMRS) is a science and technology leader in the research, development and production of sustainable ingredients for the Clean Health & Beauty and Flavors & Fragrances markets. Amyris uses its proprietary Lab-to-Market synthetic biology platform, comprised of state-of-the-art machine learning, robotics and artificial intelligence. Our ingredients are included in over 3,000 products from the world's top brands, reaching more than 200 million consumers. Amyris is proud to own three consumer brands - all built around its No Compromise^® promise of clean ingredients: Biossance^® clean beauty skincare, Pipette^® clean baby skincare, and Purecane™, a zero-calorie sweetener naturally derived from sugarcane. For more information, please visit www.amyris.com.

Forward-Looking Statements
This release contains forward-looking statements, and any statements other than statements of historical fact could be deemed to be forward-looking statements. These forward-looking statements include, among other things, statements regarding future events, such as Amyris's 2021 financial outlook and goals; Amyris's expectation that its momentum in Product revenue and completion of strategic transactions position it well to drive sector-leading growth in the future; Amyris's anticipated completion of strategic transactions and achievement of future milestones and the timing thereof; and other expectations regarding financial and operational results and strategic priorities in 2021 and beyond. These statements are based on management's current expectations and actual results and future events may differ materially due to risks and uncertainties, including risks related to Amyris's liquidity and ability to fund operating and capital expenses, risks related to its financing activities, risks related to potential delays or failures in completing and integrating planned acquisitions, risks related to potential delays or failures in development, regulatory approval, launch, production and commercialization of products, risks related to Amyris's reliance on third parties (including supply chain), and other risks detailed from time to time in filings Amyris makes with the Securities and Exchange Commission, including Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. Amyris disclaims any obligation to update information contained in these forward-looking statements, whether as a result of new information, future events, or otherwise.

Amyris, the Amyris logo, No Compromise, Biossance, Pipette, and Purecane are trademarks or registered trademarks of Amyris, Inc. in the U.S. and/or other countries.

Financial Tables Follow